Compounded Semaglutide information for prescribers
The expense and the relative scarcity of the injectable GLP-1 agonists have left many patients unable to begin or continue therapy uninterrupted. These patients could benefit greatly from the potential of these medications to reduce A1C and weight.
Jensen’s Community Pharmacy’s compounding lab has a created a GLP-1 suspension for sublingual administration. This option is available for patients looking for an alternative to injectable GLP-1s.
Our compound requires a prescription in order to be dispensed.
What makes our compound different?
We only obtain Semaglutide from FDA registered sources to ensure the potency and purity of our compounded suspensions.
The vehicle to achieve absorption through the sublingual cavity is done using a base suspension, SubMagna HMW (TM). The base was researched and produced with the express purpose of carrying high molecular weight drugs, like Semaglutide, through the sublingual cavity.
Why choose our compounded sublingual suspension?
There may be concerns with other compounded GLP-1 products found on the internet. Injections, nasal sprays, and other sublingual compounds may not be right for every patient.
Injections
Nasal Sprays
Other Sublingual
Compounds
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User Friendly
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The majority of patients prefer a sublingual route of administration over injections.
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Patient Safety
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Though there are pharmacies that can dependably compound sterile products, there are other sources on the internet without a previous reputation of quality and safety. One must choose carefully from many available sources.
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Was the Semaglutide used in the compounds sourced from an FDA-registered site? This can make a difference whether the powder is tested reliably for purity and potency.
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Efficacy
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Is the compounding entity using the salt form known as Semaglutide sodium? Although there is some evidence to suggest that the base form and the salt form have similar activity, the FDA is not recommending the use of the sodium form as a substitute
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There has been an increase in calls to poison control regarding Semaglutide injections. This is likely due to multi dose vials being dispensed to patients, resulting in larger than intended doses being injected.
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Efficacy
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The molecular weight of Semaglutide is very large at 4113 g/mol. It is very unlikely that a molecule of this size would readily penetrate the nasal mucosa to get into the blood stream
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Efficacy
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The molecular weight of Semaglutide will be a problem for absorption in the sublingual cavity without an appropriate vehicle to assist in penetration.
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Patient Safety
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Some products have been made using a powerful solvent, DMSO. This chemical is indiscriminate in what it will push through the mucosa, including substances unintended at the time of dosing. DMSO is not currently recommended for oral use.
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How to Prescribe
Note: This prescription is not billable to insurance.
Semaglutide Sublingual 13-week protocol: This protocol is based on patient feedback and response to get patients to an effective maintenance dose efficiently. The following titration schedule may be changed based on tolerability of the medication and clinical effect.
1st fill
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Semaglutide 1mg/ml Suspension
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Place 0.5ml under the tongue for a minimum of 2 minutes once daily for 2 weeks then increase to 1ml once daily. Do not eat or drink anything for 30 minutes after dose
2nd fill
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Semaglutide 2mg/ml Suspension
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Place 1ml under the tongue for a minimum of 2 minutes once daily. Do not eat or drink anything for 30 minutes after dose
3rd fill
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Semaglutide 3mg/ml Suspension
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Place 1ml under the tongue for a minimum of 2 minutes once daily. Do not eat or drink anything for 30 minutes after dose
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Maintain dosage of 3mg daily thereafter
Last updated 4/19/2024. Check back for updates on available formulas.
Questions? We're here to help!
If you have any questions about our pharmacy, our compounds, or the prescription writing process, feel free to give us a call or complete the contact form below. We look forward to talking with you!
No compounded medication is reviewed by FDA for safety or efficacy.