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Compounded Semaglutide information for prescribers

The expense and the relative scarcity of the injectable GLP-1 agonists have left many patients unable to begin or continue therapy uninterrupted. These patients could benefit greatly from the potential of these medications to reduce A1C and weight. 
Jensen’s Community Pharmacy’s compounding lab has a created a GLP-1 solution for diabetes and weight management. Our compounded Semaglutide suspension for sublingual administration is an excellent option for patients looking for an effective alternative to injectable GLP-1s.

What makes our compound different?

We only obtain Semaglutide from FDA registered sources to ensure the potency and purity of our compounded suspensions.
The vehicle to achieve absorption through the sublingual cavity is done using a base suspension, SubMagna HMW (TM). The base was researched and produced with the express purpose of carrying high molecular weight drugs, like Semaglutide, through the sublingual cavity, effectively and safely.

Why choose a sublingual route of administration?

The sublingual route that we compound is safe and effective. There are many concerns with other compounded GLP-1 products in the marketplace including injections and nasal sprays.


Nasal Sprays

Other Sublingual


  • User Friendly

    • The majority of patients prefer a sublingual route of administration over injections.

  • Patient Safety

    • Though there are pharmacies that can dependably compound sterile products, there are other sources on the internet without a previous reputation of quality and safety. One must choose carefully from many available sources.

    • Was the Semaglutide used in the compounds sourced from an FDA-registered site? This can make a difference whether the powder is tested reliably for purity and potency.

  • Efficacy

    • Is the compounding entity using the salt form known as Semaglutide sodium? Although there is some evidence to suggest that the base form and the salt form have similar activity, the FDA is not recommending the use of the sodium form as a substitute

    • There has been an increase in calls to poison control regarding Semaglutide injections. This is likely due to multi dose vials being dispensed to patients, resulting in larger than intended doses being injected.

  • Efficacy

    • The molecular weight of Semaglutide is very large at 4113 g/mol.  It is very unlikely that a molecule of this size would readily penetrate the nasal mucosa to get into the blood stream

  • Efficacy

    • The molecular weight of Semaglutide will be a problem for absorption in the sublingual cavity without an appropriate vehicle to assist in penetration.

  • Patient Safety

    • Some products have been made using a powerful solvent, DMSO. This chemical is indiscriminate in what it will push through the mucosa, including substances unintended at the time of dosing. DMSO is not currently recommended for oral use.

How to Prescribe

Note: This prescription is not billable to insurance.

Semaglutide 1mg/ml administered sublingually for at least 2 minutes, up to 5 minutes, once daily.
The longer the suspension is held under the tongue the better overall absorption.
Take 0.3ml for 1 week then increase to 0.5ml. May increase by 0.5ml every 4 weeks for clinical effect.

Check back for updates on available formulas.

Via Phone

Call the pharmacy for assistance and we can turn your verbal order into a prescription.

Via Fax

Fill out and sign the available template and fax to our Saline location at 734-944-3934.

Via E-Script

Click the button below to view detailed e-script instructions.

Questions? We're here to help!

If you have any questions about our pharmacy, our compounds, or the prescription writing process, feel free to give us a call or complete the contact form below. We look forward to talking with you!

RYBELSUS®, OZEMPIC® and WEGOVY® are all registered trademarks of Novo Nordisk A/S. MOUNJARO® and ZEPBOUND™ are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates. No compounded medication is reviewed by FDA for safety or efficacy.

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