Compounded semaglutide information for prescribers
The expense and the relative scarcity of the injectable GLP-1 agonists have left many patients unable to begin or continue therapy uninterrupted. These patients could benefit greatly from the potential of these medications to reduce A1C and weight.
Jensen’s Community Pharmacy’s has compounded GLP-1 options available including an injectable form sourced from a 503b compounding pharmacy and a sublingual (under the tongue) form from our own compounding lab.
This medication requires a prescription to be dispensed.
Sublingual semaglutide
We only obtain the semaglutide ingredient for our sublingual compound from FDA-registered sources to ensure the potency and purity of our compounded suspensions.
The vehicle to achieve absorption through the sublingual cavity is done using a base suspension, SubMagna (TM) HMW. The base was researched and produced with the express purpose of carrying high molecular weight drugs, like semaglutide, through the sublingual cavity.
Injectable semaglutide
We source our compounded injectable semaglutide from a 503B compounding pharmacy. A 503B pharmacy is registered with the FDA as a compounding outsourcing facility. They operate on a large scale to make the compounds available to other pharmacies. Note that the individual compounds are not FDA approved.
How to Prescribe
Note: This prescription is not billable to insurance.
Compounded Semaglutide for Sublingual Administration
The following protocol is to help guide therapy. There is a wide variation on patients response to semaglutide. There are also inter-patient variables that may influence the absorption of semaglutide via sublingual administration
Compounded Semaglutide in SubMagna™ HMW suspension | 10mg/ml
GLP-1 Naive Protocol
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Weeks 1-4: Take 0.25ml daily. Assess efficacy for patient and increase if needed.
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Weeks 5-8: Take 0.5ml daily. Assess efficacy for patient and increase if needed.
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Weeks 9-12: Take 0.75ml daily. Assess efficacy for patient and increase if needed.
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Weeks 13+: Take 1ml daily.
If patient has been on GLP-1 medication recently:
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Suggested to start at 3 to 5mg daily depending on strength and duration of previous GLP-1
Compounded Semaglutide for Injection
This medication must be drawn up into syringe from a multi-dose vial by patient for each dose. The syringes used are insulin syringes so the volume is converted into “Units” to be easily read. Recommend sublingual route if patient is unable to manipulate syringes or vision issues that would make reading volumes difficult.
Recommended dosage:
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Concentration of 2.5mg/ml
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0.25mg (10 Units) once weekly x 4 weeks
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0.5mg (20 Units) once weekly x 4 weeks
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1mg (40 Units) once weekly x 4 weeks
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1.75mg (70 Units) once weekly x 4 weeks
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2.25mg (90 Units) once weekly x 4 weeks
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Last updated 11/14/2024. Check back for updates on available formulas.
Questions? We're here to help!
If you have any questions about our pharmacy, our compounds, or the prescription writing process, feel free to give us a call or complete the contact form below. We look forward to talking with you!
No compounded medication is reviewed by the FDA for safety or efficacy.